Who’s Afraid Of Science Studies?

A very interesting article was published recently on the New England Journal of Medicine, with a historical view of the development and importance of randomized clinical trials in medicine: Bothwell LE, Greene JA, Podolsky SH, Jones DS. Assessing the Gold Standard — Lessons from the History of RCTs. N Engl J Med 2016; 374:2175-2181 DOI: 10.1056/NEJMms1604593

The abstract: “Over the past 70 years, randomized, controlled trials (RCTs) have reshaped medical knowledge and practice. Popularized by mid-20th-century clinical researchers and statisticians aiming to reduce bias and enhance the accuracy of clinical experimentation, RCTs have often functioned well in that role. Yet the past seven decades also bear witness to many limitations of this new ‘gold standard.’ The scientific and political history of RCTs offers lessons regarding the complexity of medicine and disease and the economic and political forces that shape the production and circulation of medical knowledge.

Three of the authors have medical degrees, I know one of them – Greene – who is a young, brilliant historian of medicine (his book Prescribing by Numbers made me rethink my own considerations on the definition of disease in contemporary medicine), who cannot therefore be accused of ignoring the subject matter they write about. In effect, they produced a solid, scholarly review of the subject. The article seems to me as non-controversial as may be, considering past considerations from mainstream authors about the whole enterprise of conducting clinical trials, such as the proposal by Richard Smith, former editor of the BMJ, of an outright moratorium in publishing their results since they became, in his words, a mere marketing tool for the pharmaceutical industry (see Smith R. Medical journals are an extension of the marketing arm of pharmaceutical companies. PLoS Med. 2005;2(5):138. DOI:10.1371/journal. Pmed.0020138).

But this well-founded discussion was met with a conniption in some quarters. A blogger wrote a piece criticizing the NEJM for having published it (The NEJM and Clinical Trials: What’s Going On?), from which I would like to quote just a tiny bit: “That, to me, is the social science worldview in a nutshell – that everything, simply everything, is deeply entangled in social conditions, economics, and politics. Take an NMR spectrum? A political act. Weigh out some copper sulfate? Politics. I sometimes think that that’s my vision of Hell. (…) Behind some of this stuff is a worldview that holds that there isn’t such a thing as ‘knowledge’ at all, just power struggles and wishful thinking.

This is in my opinion as willfuly ignorant as the blogger who stated that she wouldn’t eat anything she could not pronounce. The whole field of science studies is reduced to this ridiculous caricature by someone who clearly refuses to engage seriously with the discussion proposed by those who work in that area. Yes, science does have political and economical underpinnings, and failing to acknowledge that can lead to scientism and excessive medicalization. I really believed that the “Science Wars” of the nineties were over, but apparently not everyone got the memo.

The issue here is not that there is no such a thing as “knowledge”, but that we have to examine what we call “knowledge”, how it is produced, how it circulates among different social groups and what are the consequences of its use. Redefining the threshold for a given clinical parameter, for instance – say, blood cholesterol – is not an act of “pure science” (if that even existed), it is a negotiated process, an idea that seems to give that blogger the heebiejeebies, but that was apparently supported, for instance, even by a relatively conservative author such as Karl Popper, who wrote that “scientific objectivity can be described as the inter-subjectivity of scientific method” (“The sociology of knowledge” in Stehr N, Grundmann R. (orgs) Knowledge: critical concepts. Volume V: Sociology of Knowledge and Science. New York: Routledge, 2005, p. 68).

And that redefinition has very concrete consequences, like almost tripling the number of candidates to be treated with statins, something with obvious economic and political implications, which are present, even if implicitly, in the process of negotiating the “new normal”. At every corner multiple interests intersect in the path of the production of scientific “knowledge”, especially in Medicine, and ignoring this can be naively dangerous. Examples of how clinical trials have been manipulated over time abound, and even when they are done with the appropriate methodological concerns, they are not Revealed Truth, but a relevant guide for clinical action with important limitations. Acknowledging such limitations and the complex interactions that go into making science, on the other hand, does not mean denying that reliable “knowledge” that can be acted upon does not exist, but quite the contrary. Two exponents of the field that was simplistically panned by the author of that blog post, Harry Collins and Trevor Pinch, have a position that I subscribe wholeheartedly (I have been using this citation so much – with due credit, of course – that I fear one of this days they will ask me for copyrights…), expressed as follows: “Science may be wrong (…) but this does not make the opposite view right. In the absence of careful research about the opposite view, science is probably the way to bet. This is even more likely to be the case if science is continually put under scrutiny.” in Colins H & Pinch T. Dr. Golem: How To Think About Medicine. Chicago: The University of Chicago Press, 2005 (p. 202)

And while we are at it, what is “knowledge” anyway? Answering this is in itself a philosophical question of the type clearly despised by our colleague, but I’ll leave that for another day.

POST-SCRIPTUM: After having posted this, I recalled reading a post by PZ Myers that addressed a similar problem, and I found it: Emotionally invested in despising philosophy. He writes “Yet again, people are asking why are so many smart people such idiots about philosophy? I have a different answer than you’ll find at that link. It’s because so many smart people are idiots about psychology. I deal with a lot of atheists, and one of the many flaws in that group that have been coming to the fore lately is the obliviousness they have to their own motivations. Atheists are all about the scienceyness. Good people are rational, objective, and unemotional, which whether they are aware of it or not, is a value judgment built on emotion. There is a lot of self-esteem-building going on, centered around who is smarter than who, who can build the most logical argument, and who is best at being aloofly superior. It’s all very annoying.

Very annoying, indeed.

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“Health” Lunacy On The Internet

Few things piss me off as much as false “cures” or “treatments”, and the advent of the internet made things much worse. I gave some examples a few days ago (Cancer Quackery), but there is a never ending well of BS in the bowels of the network. A lot of this is related to a antiscience streak that underlies a lot of the misinformation that goes around (see another post, The Worrying Growth Of Antiscience Claims). I don’t see many people shopping around for “alternative airplane pilots” to fly them around or “alternative engineers” to design and supervise construction of their apartment, but that’s beside the point.

The proliferation of “detox” and “natural” remedies on the internet would be a laughing matter if it weren’t the very serious consequences they may bring about, either by being harmful, wasteful or simply delaying the beginning of proper care, and for more often than not making victims among the most vulnerable and/or desperate people. I’ll just give a few examples from some quasi-random stuff I came across.

First, the most unbelievable proposition about “cures” I’ve seen in recent times, the idea that industrial bleach is a panacea, especially for autism. Yes, you read it right: ‘Miracle cure’ exposed as bleach. More about it here: Autism: how unorthodox treatments can exploit the vulnerable. “As a rule of thumb, the more desperate and vulnerable you are the easier you are to exploit, with anything from financial advice to lifestyle tips. A diagnosis of an incurable disease; a child with a serious developmental disorder: these are circumstances that see many people seek unorthodox solutions, either as a way of coming to terms with what has happened, or in an attempt to find a treatment that perhaps the mainstream has not yet embraced, but which will give relief or cure. However, some alternative products and techniques are not merely controversial, they are potentially dangerous. Recently in mainland Ireland, a number of parents have been interviewed by police as part of an on-going investigation with the Health Products Regulatory Authority. These parents are thought to have administered a substance known as MMS to their autistic children. MMS has been known variously as Master Mineral Solution, Miracle Mineral Solution and Miracle Mineral Supplement.

Another favourite is this staple of “natural treatments”, coffee enemas (!). There’s no good reason to squirt coffee up your ass. “Potential side-effects from squirting coffee up your asshole include: ‘electrolyte imbalance, sepsis, colon or rectal perforation, and proctocolitis due to the coffee itself, among others, up to and including death.’ Coffee will not ‘detox’ you because detoxing is bullshit. It wouldn’t matter, except quacks tell cancer patients and other people who are sick and need actual medicine, not coffee enemas, to squirt coffee up their assholes.

This unfortunately applies to some mainstreamed forms of therapy that apparently either don’t know or don’t want to conduct an honest trial: New Study on Homeopathic Cough Syrup for Children Reveals a Lack of Effectiveness and Ethics. “In case you didn’t catch that, they concluded that the homeopathic cough syrup worked in the current study’s pediatric population because the subjects did as well as the adults in the ‘treatment’ arm of their prior study. The prior study, like the overwhelming majority of homeopathy research, was entirely consistent with the much more plausible conclusion that the minimal clinical effect was a mixture of placebo effects and statistical noise. All the subjects in both studies simply followed the expected course of cough symptoms caused by colds when no treatment is provided.

This extends to all sorts of diets and concoctions, perfectly satirized by an actual dietitian: Broccoli is bad for you, like, really toxic bad. “The Internet proliferates with opinion pieces quick to vilify particular foods and nutrients as being ‘the cause’ of many of our health problems by over-cooking (see what I did there?) one side of the research evidence. To show you how this is done, I present for you today a masterclass on this art form. I’ll also give you some practical tips on how to spot when it is being done.

Very dangerous “advice” is being dispensed on the internet, so caveat emptor. In closing, I feel the same way as the author of this post: Distilled nonsense. “Why are ‘health’ sites so full of shit? It’s getting to be the case that when I see ‘health’ (or worse, ‘wellness’) in the title of an article, I have the same aversive reaction I get when I see the word ‘family’. It’s a good word that has been hijacked by loons.